A Quality Product from
Panacea Biotec Ltd. [View Profile]
New Delhi - India
These are nimesulide flavoured tablets which are mouth dissolving. Nimulid-MD is pale yellow coloured, flavoured, round, biconvex, uncoated tablet, plain on both sides. Once placed on the tongue, the matrix of the tablets rapidly absorbs liquid and disintegrates. The drug, in a stabilized, size-reduced form ensures an optimal drug suspension, dissolves rapidly in less than 60 seconds.
Each uncoated flavored dispersible tablet contains:
Nimulid-MD appears to exert its therapeutic effects through a variety of mechanisms viz: selective cyclooxygenase 2 inhibition; inhibition of generation of superoxide anions from stimulated polymorphonuclear leucocytes; Inhibition of platelet activating factor synthesis; prevention of bradykinin/cytokine induced hyperalgesia of nerves (Inhibiting release of TNF-a ); Scavenging of hypochlorous acid; blocking of histamine release; prevention of cartilage damage by inhibition of metalloprotease synthesis; phosphodiesterase type IV inhibition.
After oral administration of Nimesulide, 50 to 200 mg to healthy adult volunteers, peak serum concentrations of 1.98 to 9.85 mg/L are achieved within 1.22 to 3.17 hours. Oral drug absorption is nearly complete and concomitant administration of food may decrease the rate, but not the extent of absorption of Nimesulide. The drug is extensively bound (99%) to plasma proteins and has an estimated apparent volume of distribution of 0.19 to 0.35 L/kg following oral administration. Nimesulide is extensively metabolized (1 to 3% of a dose is excreted unchanged in the urine) to several metabolites, which are excreted mainly in the urine (? 70%) or the faeces (?20%). The drug is almost completely biotransformed into 4-Hydroxy-Nimesulide in both free and conjugated forms and this metabolite appears to contribute to the anti-inflammatory activity of the compound. Peak concentrations of 4-Hydroxy-Nimesulide ranged from 0.84 to 3.03 mg/L and were attained within 2.61 to 5.33 hours after oral administration of Nimulid-MD 50 to 200 mg to healthy adult volunteers. The elimination half-life of 4-Hydroxy-Nimesulide ranges from 2.89 to 4.78 hours and is generally similar to or slightly higher than that of the parent compound (1.56 to 4.95 h).
The pharmacokinetic profile of Nimesulide is not significantly altered in children, elderly volunteers and patients with moderately impaired renal function [creatinine clearance 1.8 to 4.8 L/h (30 to 80 ml/min)].
Nimulid-MD is indicated in the treatment of variety of painful inflammatory conditions such as osteoarthritis, rheumatoid arthritis, dental surgery, upper airway inflammation, dysmenorrhoea, tonsillitis, post operative pain, sports injuries, sore throat & pharyngitis. Nimulid-MD tablet is suitable for various type of patients having difficulty in swallowing, bed ridden, have discomfort, feel nausea, don?t feel like taking tablet. Another advantage of Nimulid-MD is that it can be taken without any consumption of water or liquid. Nimulid-MD may be used at anytime, anywhere and in any situation.
Nimulid-MD is contraindicated in patients with active peptic ulcer disease, hepatic impairment & severe renal failure.
The most common adverse reactions are gastrointestinal disturbances (epigastralgia, heart burns, nausea, diarrhoea and vomiting). Dermatological reactions include rash and pruritus; central nervous system associated side effects are dizziness, somnolence and headache. Occassionally, excessive perspiration, flushing, hyperexcitability and sleep disorders have been reported. Rarely, a rise in liver enzyme levels have also been reported.
Dosage and Administration:
The usual oral dosage of Nimesulide in adults is 100 to 200 mg twice daily.
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Panacea Biotec Ltd. deals in :
Manufacturer and marketer of branded vaccines, pharmaceutical and biotechnology-based products : Tablets, Capsules, Liquid orals (bottles), Gel/Ointment (tubes), Vaccines (doses), Recombinant Proteins (doses) Pain Management : Nimulid :- Nimulid Tablet, Nimulid MD, Nimulid MR, Nimulid Transgel, Nimulid Nugel, Nimulid SP, Nimulid Safeinject, Willgo, Kondro, Upright Diabetes Management : Glizid :- Glizid, Glizid 40, Glizid - M, Glizid MR 30, Glizid MR 60, Oglo, Betaglim, Rosimet, Metlong, Heartfelt, Betaglim - M, Pioryl, Myelogen, Myelogen Injection, Lower, Lower Forte Anti-bactrials : Mygat :- Mygat Tab, Mygat I.V. Anti-Osteoporotic : Alphadol, Alphadol C, Calcom Vaccines : Enivac HB, Enivac HB Safsy, Ecovac - 4, Ecovac Safsy, Easyfour, Easyfive Renal - disease management : Panimun Bioral, Mycept, Efecient, PanGraf Anti-pyretic, Anti-inflamatory , Analgesic : Nimulid Suspension, Nimulid MD Kid Tab Anti-tubercular : Myser, Myobid, Xeed - 2, Xeed -3, Xeed -4 Constipation : Livoluk- 60ml, Gush Cough and cold : toff MD Anti-allergic : Awayke MD, Ralif ? Giro, Ocimix, ThankGod Piles Management System Kit?, ThankGod Relief Capsules?, ThankGod Anytime Cream?, ThankGod Ispaghula Husk?, ThankGod Pain & Itch Relief Cream?.
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